Visual Proteomics: Observing Protein Location in Living Cells 2

Observing proteins with precision in living cells has been a challenge for researchers across various disciplines. Now, Stefan Kubicek, PhD, and his team at CEMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, have created a new approach called visual proteomics cells (vpCells) that can fluorescently label proteins without impeding their endogenous function or regulatory mechanisms. Their study, “Pooled multicolor tagging for visualizing subcellular protein dynamics,” was published in Nature Cell Biology. Kubicek emphasized the method’s potential for future applications in both fundamental research and drug discovery. “These results provide a first glimpse into the versatility of the vpCells method,” said Kubicek. “We expect many more future applications, from fundamental cell biology to applied drug discovery.”

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